Publications

HSDiagnomics is constantly looking for interesting projects with partners from academia or companies. We are carrying out a number of research projects with focus on cancer and diseases with autoimmune background.

Publications since 2014 with a significant contribution by people from HSDiagnomics are listed below.

  • T-cell receptors identified by a personalized antigen-agnostic screening approach target shared neoantigen KRAS Q61H. V. Lennerz, C. Doppler, M. Fatho, A. Dröge, S. Schaper, K. Gennermann, N. Genzel, S. Plassmann, D. Weismann, S. W. Lukowski, D. Bents, C. Beushausen, K. Kriese, H. Herbst, V. Seitz, R. Hammer, P. J. Adam, S. Eggeling, C. Wölfel, T. Wölfel, S. Hennig. BioRxiv, Sept 21 2024.

    doi: https://doi.org/10.1101/2024.09.19.612910.

  • Specific T-cell receptor ß-rearrangements of gluten-triggered CD8+ T-cells are enriched in celiac disease patients' duodenal mucosa. V Seitz, K Gennermann, S Elezkurtaj, D Groth, S Schaper, A Dröge, N Lachmann, E Berg, D Lenze, A A Kühl, C Husemann, K Kleo, D Horst, V Lennerz, S Hennig, M Hummel, M Schumann. Clin. Immunol. 2023 Sep 27:256:109795. doi: 10.1016/j.clim.2023.109795.
  • Reconstitution of EBV-directed T cell immunity by adoptive transfer of peptide-stimulated T cells in a patient after allogeneic stem cell transplantation for AITL. María Fernanda Lammoglia Cobo, Julia Ritter, Regina Gary, Volkhard Seitz, Josef Mautner, Michael Aigner, Simon Völkl, Stefanie Schaffer, Stephanie Moi, Anke Seegebarth, Heiko Bruns, Wolf Rösler, Kerstin Amann, Maike Büttner-Herold, Steffen Hennig, Andreas Mackensen, Michael Hummel, Andreas Moosmann, Armin Gerbitz. PLoS Pathog. 2022 Apr 22;18(4):e1010206.
  • Treatment with ribociclib shows favourable immunomodulatory effects in patients with hormone receptor-positive breast cancer-findings from the RIBECCA trial. Caroline A Peuker, Sarvenaz Yaghobramzi, Corinna Grunert, Luisa Keilholz, Enio Gjerga, Steffen Hennig, Sigrid Schaper, Il-Kang Na, Ulrich Keller, Sara Brucker, Thomas Decker, Peter Fasching, Tanja Fehm, Wolfgang Janni, Sherko Kümmel, Andreas Schneeweiss, Martin Schuler, Diana Lüftner, Antonia Busse. Eur J Cancer. 2022 Feb;162:45-55
  • Evidence for a role of RUNX1 as recombinase cofactor for TCRß rearrangements and pathological deletions in ETV6-RUNX1 ALL. Seitz V, Kleo K, Droge A, Schaper S, Elezkurtaj S, Bedjaoui N, Dimitrova L, Sommerfeld A, Berg E, von der Wall E, Müller U, Joosten M, Lenze D, Heimesaat MM, Baldus C, Zinser C, Cieslak A, Macintyre E, Stocking C, Hennig S, Hummel M.  Sci Rep. 2020;10(1):10024. <Free article>
  • T-cell repertoires in refractory coeliac disease. Ritter J, Zimmermann K, Jöhrens K, Mende S, Seegebarth A, Siegmund B, Hennig S, Todorova K, Rosenwald A, Daum S, Hummel M, Schumann.  Gut. 2017 Feb 10. Feb 10. [Epub ahead of print] PubMed PMID: 28188172. <Free article>
  • A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma.     Joosten M, Ginzel S, Blex C, Schmidt D, Gombert M, Chen C, Linka RM, Gräbner O, Hain A, Hirsch B, Sommerfeld A, Seegebarth A, Gruber U, Maneck C, Zhang L, Stenin K, Dieks H, Sefkow M, Münk C, Baldus CD, Thiele R, Borkhardt A, Hummel M, Köster H, Fischer U, Dreger M, Seitz V.    Mol Oncol. 2016 Oct;10(8):1232-44.
  • The ORFeome Collaboration: a genome-scale human ORF-clone resource.      Wiemann S, Pennacchio C, Hu Y, Hunter P, Harbers M, Amiet A, Bethel G, Busse M, Carninci P, Dunham I, Hao T, Harper JW, Hayashizaki Y, Heil O, Hennig S, Hotz-Wagenblatt A, Jang W, Jöcker A, Kawai J, Koenig C, Korn B, Lambert C, LeBeau A, Lu S, Maurer J, Moore T, Ohara O, Park J, Rolfs A, Salehi-Ashtiani K, Seiler C, Simmons B, van Brabant Smith A, Steel J, Wagner L, Weaver T, Wellenreuther R, Yang S, Vidal M, Gerhard DS, LaBaer J, Temple G, Hill DE.    Nat Methods. 2016 Feb 25;13(3):191-2.
  • Donor CD4 T Cell Diversity Determines Virus Reactivation in Patients After HLA-Matched Allogeneic Stem Cell Transplantation.     Ritter J, Seitz V, Balzer H, Gary R, Lenze D, Moi S, Pasemann S, Seegebarth A, Wurdack M, Hennig S, Gerbitz A, Hummel M.   Am J Transplant. 2015 Aug;15(8):2170-9.
  • A new method to prevent carry-over contaminations in two-step PCR NGS library preparations.    Seitz V, Schaper S, Dröge A, Lenze D, Hummel M, Hennig S.   Nucleic Acids Res. 2015 Jul 7. <Free article> 
  • Abnormally differentiated CD4+ or CD8+ T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency.    Rensing-Ehl A, Völkl S, Speckmann C, Lorenz MR, Ritter J, Janda A, Abinun M, Pircher H, Bengsch B, Thimme R, Fuchs I, Ammann S, Allgäuer A, Kentouche K, Cant A, Hambleton S, Bettoni da Cunha C, Huetker S, Kühnle I, Pekrun A, Seidel MG, Hummel M, Mackensen A, Schwarz K, Ehl S. Blood. 2014 Aug 7;124(6):851-60.

 

 

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HSDiagnomics

News

06/2024
Project Update: HS Diagnomics has entered into the international collaborative project ELEVATE with TU Wien, NMI Tübingen, Sciospec, UpNano, and THT Biomaterials
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10/2023
HSDiagnomics partners with Charité University Medicine Berlin, TheryCell GmbH, and EPO GmbH in an innovative project to advance TCR-T therapy for solid tumors
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06/2020
TCRsafe® analysis of a Runx1 knockout mouse model provides evidence for a role of RUNX1 as a recombinase cofactor for TCRß rearrangements and pathological deletions
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08/2019
ZIM-Project TCR-specific Antigen Identification - TAgID
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04/2018
Patent granted for the identification of tumor-specific T-cell receptors
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